J. Chem. En. Sci. A.

Synthesis, Characterization and Biological Evaluation of Some Novel Chalcone Derivatives Containing Imidazo[1,2-a]Pyridine Moiety

Rajesh G. Rupala, Dinesh S. Kundariya and Praful K. Patel

  • Download PDF
  • DOI Number
    https://doi.org/10.15415/jce.2014.11003 
KEYWORDS

Chalcone, arylmethyl ketone, arylaldehyde, antimicrobial.

PUBLISHED DATE September 2014
PUBLISHER The Author(s) 2014. This article is published with open access at www.chitkara.edu.in/publications
ABSTRACT

Chalcone was prepared by the condensation of arylmethyl ketone and arylaldehyde in the presence of alcoholic alkali. Present study describes the synthesis of a series of (2z)-3-[2-(4-chlorophenyl)-8-methyl imidazo[1,2-a] pyridine-3-yl]-1-substituted arylprop-2-en-1-one compounds (h) 1-9. The compounds were characterized by modern analytical techniques such as CHN analyses, IR, 1H NMR spectra and further supported by mass spectroscopy. All the title compounds were screened for their in vitro antibacterial and antifungal activity against B.coccus, S.aureus, Pseudomona, E.coli, A.niger, Ampicillin, Amoxicillin, Ciprofloxacin, Norfloxacin, Greseofulvin. Their minimum inhibitory concentrations (MIC) were determined. The results of antibacterial activity showed that compounds h 4, h 9 and antifungal activity compounds h 1, h 9 using standard drug.

Page(s) 23–32
URL http://dspace.chitkara.edu.in/jspui/bitstream/1/516/3/11003_JCE_Rajesh.pdf
ISSN Print : 2349-7564, Online : 2349-7769
DOI https://doi.org/10.15415/jce.2014.11003 
REFERENCES
  • Abdet Rahman, T. N. (1998) Bull. Chim. Farm.; (2000) Chem. Abstr., 132, 93276h.
  • Auto, R. J. et al.(1994) J. Clin. Biochem. Nutr., 17(2), 73; (1995) Chem. Abstr., 123, 122487x.
  • Bell, M. R. (1984) US Appl., 637, 931 ; (1990) Chem. Abstr., 113, 211828t.
  • Binder, D., Noe, C. R., Holzer, W. and Rosenwirth, B. (1985) Arch. Pharm. 318(1), 48; (1985) Chem. Abstr., 102, 149025u.
  • Bombardelli, E., Piero, V. (1999) PCT Int. Appl. WO 98, 58, 913; Chem. Abstr., 130, 95382r.
  • Bowden, K., P., Dal, P. A. and Shah, C. K. (1990) J. Med. Res. Synop., 12, 2801; (1991) Chem. Abstr., 114, 160570m.
  • Breslow, D. S. and Houser, C. R. (1940) J. American Chem. Soc., 62, 2385; Chem. Abstr., 34, 7875.
  • Cheng, P. L., Fournari, P. and Tirouflet, J. (1963) Bull. Soc. Chim. France, 102248; (1964) Chem Abstr., 60, 1683.
  • Dimmock, J. R., Elisk, M., U. S. US 6, 017, 933; (2000) Chem. Abstr., 132, 107880n.
  • Gaurav, V. M. and Ingle, D. B (1986) Indian J. Chem., 25B, 86; (1987) Chem. Abstr., 107, 3932h.
  • Hemes, S. A. (1969) Chem Abstr., 70, 96422h.
  • Inamori, Y. et al. (1991) Chem. Pharm. Bull., 39(6), 1604; (1991) Chem. Abstr., 115, 105547c.
  • Jadav, G. V. and Kulkarni, V. G. (1944) Curr. Sci.
  • Kalashnikov, B. B., Kalashnikov, I. P. (1994) Chem. Abstr., 130, 296596n.
  • Kazauki, K., Htayama, K., Yokomor, S. and Soki, T. (1976) Chem Abstr., 85, 5913.
  • Ko Horng-Huey, Tsao Lo- Ti, Yo Kum- Lung, Cheng-Tsung, Wong J. P., Lin C. N. (2003)
  • Bioorg. & Med. Chem., 11(1), 105-111; (2003) Chem. Abstr., 139, 30144.
  • Kostanecki, S. V. and Tambor, J. (1899) Chem. Ber., 32, 1921.
  • Kumar Srinivas, K., Hanger, E., Pehit, C., Gurulingoppal, H., Davidson, N. E., Khan, S. R. (2003) J. Med. Chem., 46(14), 2813-15; (2003) Chem. Abstr., 139, 117464.
  • Kurodo, C. and Matsukuma, T. (1932) Sci. Papers Inst. Phys. Chem. Res. (Tokyo), 18, 51; (1932) Chem. Abstr., 26, 2442.
  • Li Rongshi, Chen. Xiawa., Gong Baogung, Qominguez, Jose N. et al (1995) J. Med. Chem., 38(26), 5031-7; (1996) Chem. Abstr., 124, 232f.
  • Lin Yuh-Meei, Zhou Yasheen, Flavin M. T. Zhou L. M. Nie, W., Cheng, F. C. (2002) Bioorg. & Med. Chem., 10(8), 2795-2802; (2003) Chem. Abstr., 138, 66146.
  • Lyle, R. B. and Paradis, L. P. (1955) J. American Chem. Soc., 77, 6667; (1956) Chem Abstr., 50, 10057.
  • Nakahara Kazuhiko, Torakoontiwakon G., Kaneyama M. , Ono Hiroshi, Yoshida Mitsuru (2003)
  • Jpn. Kokai Tokkyo Koho JP 03, 040829; (2003) Chem. Abstr., 138, 158753.
  • Ni Liming, Worsencrott, K. J., Weingarten, M. D., Meng. C. Q., Sikorski, J. A. (2002) U. S. US. WO. 02, 41336; (2003) Chem. Abstr., 139, 85160.
  • Nissan Chemical Industries (1983) Chem. Abstr., 98, 178947a.
  • Ogansyan, E. T. et al (1991) Khim. Farm. Zh., 25(8), 18; (1991) Chem. Abstr., 115, 247497n.
  • Pedersen, A. K. and Fitz Gerald, G. A. (1985) J. Pharm. Sci., 74(2), 188; (1985) Chem. Abstr.,103, 87592m.
  • Rawal, A. A. and Shah, N. M (1962) Indian J. Chem., 21, 234.
  • Reichel, L. (1944) Naturwissenschallen, 32, 215; (1946) Chem. Abstr., 10, 2441.
  • Rupe, H. and Wasserzug, D. (1901) Chem Ber., 34, 3527.
  • S. Elichi, S., K. Koji, K. (2000) PCT Int. Appl. WO 99, 61, 403 ; Chem. Abstr., 132, 12199d.
  • Satoshi, S., Yasunori, N., Hiroki, V. (1993) J. Med. Chem., 3904-9 (Eng.); (1994) Chem. Abstr., 120,