J. Chem. En. Sci. A.

Synthesis and Characterization of Novel Schiff base Cu(II) Complexes: Antimicrobial and Molecular docking Studies

AP Arumugam , G Elango and S Guhanathan

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  • DOI Number
    DOI https://doi.org/10.15415/jce.2017.32006

EPR, 3,4-diaminobenzophenone, Antimicrobial Activity, Molecular Docking.

PUBLISHER The Author(s) 2017 . This article is published with open access at www.chitkara.edu.in/publication

N2O2 type complexes of C+2uion have been synthesized by the reaction of Salicylaldehyde / 3,4-diaminobenzophenone / acetyl acetoneand glutaric anhydride. The ligands and respective metal complexes was established through spectroscopic data (FT-IR, UV-Vis,1H NMR and 13C NMR). They are non-electrolytic in nature as their molar conductivities (ΛM) in DMSO of 10-3 M solution from the EPR study the complexes proposed to be octahedral geometry. All the metal complexes have been screened for their antibacterial activity andthe predicted binding affinity using molecular docking studies.


Schiff base metal complexes have a huge number of synthetic uses in organic chemistry. Acylation of Schiff bases by acid anhydrides, acid chlorides and acyl cyanides is initiated by attack at the nitrogen atom and leads to net addition of the acylating agent to the C=N bond. Reactions of this type have been used for good purpose in natural product synthesis [1]. Copper is well known for bioessential element. Itscomplexes have proven to be an excellent for biological importance due to their binding ability and positive redox potential [2-5] Cu(II) metal complex exhibits the fastest water exchange rate for any transition metal hydro complexes. In recent years, many research had been carried out to study the uses of copper containing coordination complexes in various fields like medicinal, bioinorganic, catalytic and analytical chemistry [6-7].This paper concentrates on the synthesis and biological activity of Schiff baseligandsand theircopper (II) complexes.

Page(s) 75-90
URL http://dspace.chitkara.edu.in/jspui/bitstream/123456789/713/1/JCE001_Arumugam.pdf
ISSN Print : 2349-7564, Online : 2349-7769
DOI DOI https://doi.org/10.15415/jce.2017.32006

The formation of Copper (II) complexes are thermally stable. The complexes were characterized by spectral and analytical data. Based on the spectral data anCu(II) complexes assigned to thedistorted octahedral geometry, based on the biological study the complexes aregood antimicrobial agent. Binding affinity and inhibition level were determined using molecular docking study

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