Synthesis, Characterization and Biological Evaluation of Some Novel Chalcone Derivatives Containing Imidazo[1,2-a]Pyridine Moiety

  • Rajesh G. Rupala Department of Chemistry, M. M. Science College, Morbi – 363 642. Gujarat, India
  • Dinesh S. Kundariya Department of Chemistry, Tolani College of Arts and Science, Adipur (Kachchh)-370205, Gujarat, India
  • Praful K. Patel Department of Chemistry, M. M. Science College, Morbi – 363 642. Gujarat, India
Keywords: Chalcone, arylmethyl ketone, arylaldehyde, antimicrobial

Abstract

Chalcone was prepared by the condensation of arylmethyl ketone and arylaldehyde in the presence of alcoholic alkali. Present study describes the synthesis of a series of (2z)-3-[2-(4-chlorophenyl)-8-methyl imidazo[1,2-a] pyridine-3-yl]-1-substituted arylprop-2-en-1-one compounds (h) 1-9. The compounds were characterized by modern analytical techniques such as CHN analyses, IR, 1H NMR spectra and further supported by mass spectroscopy. All the title compounds were screened for their in vitro antibacterial and antifungal activity against B.coccus, S.aureus, Pseudomona, E.coli, A.niger, Ampicillin, Amoxicillin, Ciprofloxacin, Norfloxacin, Greseofulvin. Their minimum inhibitory concentrations (MIC) were determined. The results of antibacterial activity showed that compounds h 4, h 9 and antifungal activity compounds h 1, h 9 using standard drug.

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Published
2014-09-03
How to Cite
Rajesh G. Rupala, Dinesh S. Kundariya, & Praful K. Patel. (2014). Synthesis, Characterization and Biological Evaluation of Some Novel Chalcone Derivatives Containing Imidazo[1,2-a]Pyridine Moiety. Journal of Chemistry, Environmental Sciences and Its Applications, 1(1), 23-32. https://doi.org/10.15415/jce.2014.11003
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Articles